Telos Rx
Ranked #5 · Grade B
Rx-Readiness86:100
A fast, fully async start with a needle-free sublingual tirzepatide option and — a genuine upgrade since our last check — flat pricing stated in writing. The catch is a state list it still won't publish.
Strut Health
Ranked #10 · Grade B−
Rx-Readiness81:100
The async, needle-optional value play: oral or injectable semaglutide and tirzepatide from a low starting price, no video visit, ~3 days to a script — listed with its February 2026 FDA warning letter in plain view.
Async-first compounded GLP-1 with a rarity for this list — free health coaching — at a flat one-price-all-doses rate. Fast and friendly up front; the strict, non-refundable fine print is the trade-off.
SnagRx
Ranked #38 · Grade C
Rx-Readiness70:100
Compounded semaglutide at $69 a month and tirzepatide at $119, one flat price that SnagRx says covers the medication, the supplies, the doctor review and shipping, with no membership fee and cancellation by email or phone. Both figures are advertised against struck-through list prices of $299 and $399 under a live countdown clock, and the promise to lock that rate for life is marketing rather than a published term. It ships from licensed US pharmacies it never names, and publishes no list of the states it serves.
Compounded semaglutide from $129 a month and tirzepatide from $199, held at the same price at every dose, plus a separate microdose line from $109 for anyone who wants a gentler metabolic effect rather than maximum weight loss. Lttl covers all 50 states and Washington D.C., says it prescribes and ships within 48 hours, and attributes compounding to U.S.A.-licensed pharmacies it does not name. The catalog runs well past weight loss into NAD+, sermorelin, glutathione and B12 from $79, so read the longevity menu as a separate business from the GLP-1 you came for. Prices are published as starting points rather than a single rate, and the first-order discount of up to $140 is promotional.
Pepti
Ranked #17 · Grade C
Rx-Readiness77:100
Pepti publishes the lowest semaglutide price in this entire roster — $99 a month, flat at every titration dose, with the medication, physician review, shipping, refill management and unlimited messaging with your prescribing doctor all inside it. Tirzepatide is $199 on the same all-in, flat-at-every-dose basis. That number is low enough to deserve skepticism, so it is worth saying exactly where it comes from: Pepti states it on a dedicated cost page, repeats it in its FAQ ('we keep pricing flat and transparent at $99/mo all-in'), and prices the comparison against Hims, Henry Meds and Mochi on the same page. It names two prescribing physicians and says its medication is compounded by FDA-registered 503A or 503B pharmacies, though it never names which. The real limits are reach and format: it ships to 36 states rather than 50, it is cash-pay only and bills no insurance, and its needle-free oral GLP-1/GIP drops cost $349 — well above its own injection.
SurpassMD
Ranked #83 · Grade C
Rx-Readiness64:100
$114 is the lowest semaglutide figure on this page, and it comes with a condition SurpassMD prints only in its FAQ: the price applies "for eligible patients with a promotion". The standing rate is published nowhere, which makes budgeting past the first cycle guesswork. What is solid: all fifty states plus DC, 503A compounding, cold-chain shipping within 48 hours of approval, HSA and FSA accepted, cancel anytime. There is an oral semaglutide as well, with no price attached.
Coivas
Ranked #41 · Grade C
Rx-Readiness69:100
Flat compounded pricing with the post-introductory number actually printed: $149 a month for semaglutide and $229 for tirzepatide, the same at every dose, after intro rates of $119 and $199. For planning purposes that flatness is the useful part — a titration step-up does not change the bill, so the number you budget in month one is the number in month six. All 50 states, and consultation, prescription, medication, shipping and support are inside the price. Watch the word "from" on every figure: the site says dosage and titration can move what you pay.
Trellis Vitality
Ranked #11 · Grade B−
Rx-Readiness81:100
Trellis Vitality is the cheapest genuinely-disclosed option on this page: $150 a month for compounded semaglutide and $199 for tirzepatide, month to month, with every dosage available at the same price and no membership fee, no consult fee and a $0 assessment. Commit for three or six months and those fall to $140/$133 and $189/$179. It names the pharmacy that compounds the medication — Vials Rx, described as a US state-licensed, cGMP-compliant facility — which is the disclosure most of its cheaper competitors skip, and it covers all 50 states with board-certified clinicians reviewing intake. The caveats are about what it doesn't sell and doesn't say. There is no FDA-approved brand option, no oral formulation, and none of its pricing appears on the homepage at all — you have to reach the GLP-1 product page to find a single number, which makes it look more opaque than it actually is. There is also no postpartum, breastfeeding or PCOS content anywhere.